Modulation of MHC Antigen Expression and DiseaseBMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7029.519 (Published 24 February 1996) Cite this as: BMJ 1996;312:519
- David R Johnson
Ed G Eric Blair, Craig R Pringle, D John Maudsley Cambridge University Press, pounds sterling50, pp 440 ISBN 0 521 49578 4
Failure is often more revealign than success. Modulation of MHC Antigen Expression and Disease succeeds in revealign a great deal about the immune system, which normally tolerates the wide variety of tissues in the body and responds against infection or tumours, by analysing failures in tolerance or response that produce disease.
The opening chapters are an excellent introduction to the genetics, biochemistry, and cellular immunology of the major histocompatibility complex (MHC). These genes encode highly polymorphic, cell surface molecules that bind peptides, facilitating their recognition by specific T lymphocytes. Class I histocompatibility …