Somatostatin in bleeding oesophageal varices

BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7028.442 (Published 17 February 1996) Cite this as: BMJ 1996;312:442

Important information about trial was omitted

  1. S A Jenkins,
  2. I N Baxter
  1. Non-clinical scientist Reader in surgery University Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER

    EDITOR,—We find it hard to understand why, in Peter C Gotzsche and colleagues' double blind placebo controlled trial of somatostatin in acute variceal haemorrhage, patients were not randomised for long periods after the onset of haemorrhage.1 Patients with cirrhosis do not tolerate prolonged periods of bleeding.

    The authors elected not to use bolus administration of somatostatin as soon as the continuous infusion was established despite good evidence for this method of administration.2 In 19 randomised controlled trials of somatostatin …

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