Omeprazole as a risk factor for campylobacter gastroenteritis: case-control study
BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7028.414 (Published 17 February 1996) Cite this as: BMJ 1996;312:414
- Keith R Neal (keith.neal@nottingham.ac.uk), lecturer in communicable disease controla,
- Helen M Scott, medical studenta,
- Richard C B Slack, consultant in communicable disease controlb,
- Richard F A Logan, reader in clinical epidemiologya
- a Department of Public Health Medicine, University of Nottingham, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH
- b Nottingham Health Authority, Nottingham NG1 6GN
- Correspondence to: Dr Neal.
- Accepted 21 July 1995
Gastric acid protects against enteric infections,1 and patients who have had gastric surgery or are taking H2antagonists are more susceptible to salmonella infection.2 3 Antibiotic treatment also increases the risk of infection.3 It is not known whether these factors are also associated with campylobacter infection, for which statutory notifications now exceed those for salmonella.4 We conducted a case-control study to assess whether gastric antisecretory drugs, antibiotics, and abdominal surgery are associated with campylobacter infection.
Patients, methods, and results
Between January 1992 and August 1994, 243 notified cases of campylobacter infection, confirmed by faecal culture, were identified in people aged 45 and over in two of the local district councils within Nottingham Health Authority. Thirty two cases were excluded (non-resident (four), general practitioner declined (19), patient died and notes unobtainable (six), and notes unobtainable at general practice (three)), leaving 211 (123 women). The …