Authors' reply

BMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7025.252 (Published 27 January 1996) Cite this as: BMJ 1996;312:252
  1. P Patel,
  2. M A Mendall,
  3. D Carrington,
  4. D P Strachan,
  5. E Leatham,
  6. N Molineaux,
  7. J Levy,
  8. C Blakeston,
  9. C A Seymour,
  10. A J Camm,
  11. T C Northfield
  1. (registrar in gastroenterology), (consultant gastroenterologist), (senior lecturer in virology), (senior lecturer in epidemiology), (senior registrar in cardiology), (research nurse), (research assistant), (research assistant), (professor in biochemistry and chemical pathology), (professor in cardiology), (professor in gastroenterology) St George's Hospital Medical School, London SW17 0RE

    EDITOR,—Brendan C Delaney and colleagues point out that the association between seropositivity for antibodies to Helicobacter pylori and coronary heart disease (based on history alone) in our study failed to reach significance. It is more important, however, to look at the odds ratio and confidence interval. We suggest that an odds ratio of 1.87 (95% confidence interval 0.87 to 4.02) is important in a common disease like coronary heart disease.

    The reason for Delaney and colleagues' failure to find an association between H pylori infection and a history of ischaemic heart disease (as ascertained from general practice records) is unclear, but selection bias may have been a problem as the subjects were all attending their general practice. …

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