Research finds genetic link to personality traitBMJ 1996; 312 doi: https://doi.org/10.1136/bmj.312.7023.75 (Published 13 January 1996) Cite this as: BMJ 1996;312:75
- Tessa Richards
The first evidence that a normal personality trait is partially medicated by genes comes from two studies, one from Israel and the other from the United States (Nature Genetics 1995;12:78-80, 81-4). Both test the hypothesis that individual variation in the “novelty seeking” trait, a normal personality characteristic that we all possess, is associated with a genetically determined variability in dopamine transmission in the brain.
Both found, in different populations of normal subjects, a significant association between high test scores on validated questionnaires measuring novelty seeking — characterised by excitable, impulsive, exploratory, and extravagant behaviour—and the presence of long alleles of D4 dopamine receptor gene exon III. Those with only short alleles had lower novelty …