Papers

Cancers coinciding with childbearing: delayed diagnosis during pregnancy?

BMJ 1995; 311 doi: https://doi.org/10.1136/bmj.311.7020.1607 (Published 16 December 1995) Cite this as: BMJ 1995;311:1607
  1. Mats Lambe, doctoral studenta,
  2. Anders Ekbom, associate professora
  1. a Department of Cancer Epidemiology, University Hospital, S-751 85 Uppsala, Sweden
  1. Correspondence to: Dr Lambe.e-mail: mats.crabix@epic.uu.se.

    Cancers associated with childbearing pose extremely difficult questions for the patient and her physician. Population based registry data gave us the opportunity to examine the incidence of this uncommon occurrence.

    Subjects, methods, and results

    Cases were identified following a linkage between the Swedish Cancer Registry and a nationwide fertility registry. Nearly all diagnosed cancers are recorded in the cancer registry.1 The fertility registry contains information on number and dates of live births for more than 2.3 million Swedish women born in 1925 and thereafter.2

    Among women born from 1925 to 1972 more than 2.7 million live births and 32848 cancers were recorded during reproductive ages (15-44 years) in 1960-90. Of all cancers, 428 (1.3%) were diagnosed during pregnancy (date of a live birth-9 months) and 1425 (4.3%) during the lactation period (date of birth+12 months). The overall incidences during pregnancy and lactation, respectively, were 15.6 and 51.6 per 100000 live births.

    Median age at diagnosis during pregnancy was 29.8 years. The most frequent sites were skin (malignant melanoma; 3.6 per 100000 live births), cervix uteri (2.4 per 100000), and breast (2.0 per 100000). About 4% of breast cancers and 10% of thyroid cancers during reproductive years were diagnosed during pregnancy or in the year after birth. The corresponding figures in the age group 25-29, when childbearing was most frequent, were 19% and 21%, respectively.

    Expected numbers during pregnancy and lactation were estimated from female age specific and period specific population rates. The observed to expected ratios during pregnancy were below unity for all of the 10 most common sites except melanoma. For all sites combined the observed to expected ratio was 0.4(9) [0.4(4)-0.5(3)]. For sites where case interval numbers indicated a deficit of recorded cases in early pregnancy (cervix uteri, breast, overy, Hodgkin's disease, leukaemias), ratios were also computed based on observed numbers in trimester 3. During the lactation period the observed to expected ratio for all sites combined was 1.2(1) [1.1(5)-1.2(8)].

    Comment

    Our findings are in broad agreement with a previous population based study that observed fewer than expected cancers during pregnancy.3 Our data indicate that a small, but not negligible, proportion of all malignancies in young women are diagnosed in association with childbearing. More importantly, the estimated observed to expected ratios suggest that diagnosis is delayed to the postpartum period. Pregnancy is usually a period of intense medical observation. However, potentially harmful diagnostic procedures are probably less likely to be implemented. Moreover, unusual signs and symptoms may be interpreted as being related to pregnancy. Given the physiological changes in the breast during childbearing this may be most evident for breast cancer; longer delays in pregnant compared with non-pregnant subjects have been reported.4 In our data, fewer cases of breast cancer were diagnosed in the first half than in the second half of the lactation period.

    An alternative explanation, but not mutually exclusive, is that tumour progression is altered during pregnancy and lactation. The growth of malignant cells, present before conception, may be stimulated by transient hormonal5 and perhaps immunological changes during childbearing.

    A limitation of our data was the lack of information on terminated pregnancies, which may have reduced the number of registered cases in the first and second trimesters. The practice of therapeutic abortions in association with malignant disease has varied according to site, stage, type of treatments available, time, and period of diagnosis. The only site where organised screening activities may have affected results is the cervix. Smear testing practices in early pregnancy have varied over time.

    Ten most common sites of cancers coinciding with childbearing: observed (O) and expected (E) numbers and ratios (and 95% confidence intervals) of these sites during pregnancy (trimesters 1-3) and lactation. Expected numbers based on general female population rates

    View this table:

    Our findings may have implications for maternity care policies. Gestational cancer is likely to become more common as women in many Western countries postpone childbearing to an older age. Better awareness among doctors, coupled with an increased readiness to evaluate unusual symptoms, may help avoid undue delay in diagnosis in this special group of patients.

    We are indebted to Mr Hakan Jansson for programming assistance.

    Funding: Supported by grants from the Swedish Cancer Society and Wahlmarks fund at the Uppsala City Council.

    Conflict of interest: None.

    Footnotes

    • Funding Supported by grants from the Swedish Cancer Society and Wahlmarks fund at the Uppsala City Council

    • Conflict of interest None.

    References

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