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  1. C J Mugglestone*, Independent consultant to pharmaceutical industry *From 1974 to 1987 C J Mugglestone worked on hormone replacement therapy projects and in postmenopausal osteoporosis with Organon, Schering Chemicals, and Brocades. Since 1987 he has worked as an independent consultant on projects that have included hormone replacement therapy.
  1. C J M Medical, Sutton, Surrey SM2 5JG

    EDITOR,--I am confused over how Klim McPherson reaches some of his conclusions, particularly the conclusion that long term use of hormonal supplements in postmenopausal women may be responsible for an average net loss of years of life.1 Far more studies have been done that show benefits of hormone replacement therapy on coronary heart disease and osteoporosis than that show benefits on breast cancer. The figures for coronary heart disease, of a 50% reduction in overall mortality,2 and the preventability of osteoporosis and fractures are reasonably believable.3 The studies …

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