Not using age specific values invalidates studyBMJ 1995; 311 doi: https://doi.org/10.1136/bmj.311.7016.1371d (Published 18 November 1995) Cite this as: BMJ 1995;311:1371
- Kevin Spencer
- Consultant biochemist Endocrine Unit, Clinical Biochemistry Department, Oldchurch Hospital, Romford, Essex RM7 0BE
EDITOR,--J Fletcher and colleagues' paper does little to help purchasing authorities when they have to decide which screening programme and screening policy to choose when introducing screening for Down's syndrome.1 While the methodology used in the paper is valuable when used correctly, the authors were wrong to apply the overall sensitivity and specificity of serum testing obtained from whole population data rather than using age specific values. They argue that “this was done to reduce complexity.” As a consequence of their not making allowance for the fact that in older women (those over …
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