Pyridoxine supplements in the carpal tunnel syndrome

EDITOR,--I confess to having started the hare that led to megadoses of pyridoxine being given in the carpal tunnel syndrome.¹ Karl Folkers visited Newcastle some 30 years ago, and when told of my recent finding that aspartate aminotransferase in necropsy tissues was only about half saturated with the coenzyme, pyridoxal phosphate, he jumped to the obvious conclusion that the subjects had been deficient in vitamin …