British aneurysm nimodipine trial reported improved clinical outcome with nimodipine

BMJ 1995; 311 doi: https://doi.org/10.1136/bmj.311.7001.388c (Published 05 August 1995) Cite this as: BMJ 1995;311:388
  1. Gordon D Murray, Director
  1. Robertson Centre for Biostatistics, University of Glasgow, Glasgow G12 8QQ

    EDITOR,--L E Wagenknecht and colleagues report a randomised placebo controlled trial, in which the calcium antagonist nimodipine was assessed as a possible neuroprotective agent during cardiac surgery.1 The trial was stopped prematurely after 149 patients had been enrolled because an interim analsis showed an excess mortality with nimodipine (eight deaths versus one). This excess mortality was strongly associated with major surgical …

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