Megatrials are subordinate to medical scienceBMJ 1995; 311 doi: https://doi.org/10.1136/bmj.311.6999.257b (Published 22 July 1995) Cite this as: BMJ 1995;311:257
- Bruce G Charlton
- Lecturer Department of Epidemiology and Public Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH
EDITOR,--Evidence based medicine started life as a flawed but marvellously refreshing approach to clinical practice and continuing education.1 Unfortunately, it has recently been taken up by politicians and managers and is rrently being packaged and promoted as a panacea, at the expense of medical science.
The main defining feature of evidence based medicine is its assertion that randomised controlled trials, especially “megatrials,” should serve …