Magnesium in acute myocardial infarction

BMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6995.1669c (Published 24 June 1995) Cite this as: BMJ 1995;310:1669
  1. Kent L Woods,
  2. D B Barnett
  1. Reader in therapeutics Professor of clinical pharmacology Department of Medicine and Therapeutics, University of Leicester, Leicester LE2 7LX

    EDITOR,—Salim Yusuf and Marcus Flather1 offer no satisfactory explanation for the statistical incompatibility (P>0.0001 for heterogeneity) between the inefficacy of magnesium in the fourth international study of infarct survival (ISIS-4)2 and the clearly positive pooled results of the 10 other trials of intravenous magnesium in acute myocardial infarction. Magnesium has been reported to protect contractile function in a dozen experimental models of myocardial ischaemia and reperfusion and is now known to act during the first few minutes of reperfusion.3 4 ISIS-4 was unique in that most …

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