Screening sperm donors for cystic fibrosisBMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6993.1533 (Published 10 June 1995) Cite this as: BMJ 1995;310:1533
- Ian Findlay,
- Howard Cuckle,
- Richard J Lilford,
- Anthony J Rutherford,
- Philip Quirke,
- Steven Lui
- Research fellow Professor of reproductive epidemiology Chairman of epidemiology and health services research Institute of Epidemiology and Health Services Research, University of Leeds, Leeds LS2 9LN
- Director, assisted conception unit Head of histopathology and molecular pathology Leeds General Infirmary, Leeds, LS1 3EX
- Senior embryologist IVF Unit, Princess Royal Hospital, Hull HU8 9HE
EDITOR,—Cystic fibrosis is the most common serious autosomal recessive condition in white populations, affecting about 1 in 2500 live births, and until recently life expectancy rarely exceeded 30 years. The most common cystic fibrosis mutation (δF508, accounting for about 80% of two million British carriers), is a 3-bp deletion in a transmembrane protein cystic fibrosis transmembrane regulator gene. The next most common three or four mutations account for a further 5% of carriers.
One in 25 white people carries cystic fibrosis. As carriers are unaffected, individuals are often unaware until …
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