Letters

Measuring cardiolipin antibodies

BMJ 1995; 310 doi: http://dx.doi.org/10.1136/bmj.310.6992.1472b (Published 03 June 1995) Cite this as: BMJ 1995;310:1472
  1. A Milford Ward,
  2. P A E White
  1. Organiser Manager United Kingdom National External Quality Assessment Scheme for Autoimmune Serology, PO Box 894, Sheffield S5 7YT

    EDITOR,—Cardiolipin antibodies have been variously cited as a risk factor for cerebral thrombosis1 2 or splanchnic venous thrombosis,3 or as an epiphenomenon loosely associated with vascular disease.4

    Cardiolipin antibodies seem to represent a family of low affinity antibodies which share a limited ability to bind to bovine cardiolipin. This rather artificial assay system, dependent on the binding of a low affinity human autoantibody to a non-primate, cross reacting substract of unproved relevance, can lead to some rather bizarre comparisons. Cardiolipin antibodies are probably identical to the chronic biological false positive Wasserman reaction described more than two decades ago in relation to systemic lupus erythematosus …

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