Authors' reply

BMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6989.1267d (Published 13 May 1995) Cite this as: BMJ 1995;310:1267
  1. L Mynors-Wallis,
  2. D H Gath,
  3. A Lloyd-Thomas
  1. Consultant psychiatrist Reader in psychiatry Research general practitioner Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX

    EDITOR,—In response to Jogin H Thakore's comments about the severity of depression, it is important to emphasise that our trial was carried out in primary care. We selected depressed patients with a score of 13 or more on the Hamilton depression rating scale because Paykel et al found in general practice that depression at this level and above responded to amitriptyline but not placebo.1 Thakore states that most investigators would regard a Hamilton score of over 18 as the minimum score for entry into a trial, but trials comparing psychological with …

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