Education And Debate

ABC of Rheumatology: RAYNAUD'S PHENOMENON, SCLERODERMA, AND OVERLAP SYNDROMES

BMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6982.795 (Published 25 March 1995) Cite this as: BMJ 1995;310:795
  1. David A Isenberg,
  2. Carol Black

    Raynaud's phenomenon

    Several rheumatological conditions are linked to impaired peripheral circulation. These abnormalities may take various forms, including chilblains, acrocyanosis, and Raynaud's phenomenon. This last condition, described by the French clinician Maurice Raynaud in 1862, occurs in up to 5% of an otherwise healthy population, but may be a link between certain autoimmune rheumatic diseases. Raynaud's disease refers to the development of trophic changes as a result of microcirculatory damage and prolonged local ischaemia. Fortunately, gangrene is relatively rare, and, because patients are often young, recovery may be remarkable.

    Disturbances of peripheral circulatory system

    Chilblains—Painful, burning or itching erythematous lesions of hands or feet (rarely ulceration) precipitated by damp and cold (especially if inadequate clothing worn)

    Acrocyanosis—Persistent cold, blue, and rather sweaty appearance, usually of hands

    Raynaud's phenomenon—Episodic, clearly demarcated two or three phase colour change—white (ischaemia), then often blue (stasis), then red (reactive hyperaemia)–of fingers and sometimes toes (rarely nose, tongue, or ears) in response to cold or, less often, emotion

    Well defined blanching of skin characteristic of Raynaud's phenomenon.

    Raynaud's phenomenon as a predictor of autoimmune rheumatic disease

    Over 90% of patients with Raynaud's phenomenon are female and, at the time of presentation, are often aged under 25. Up to 5% of patients presenting with the condition eventually develop an autoimmune rheumatic disease. The presence of abnormal nail fold capillaries (detected by capillaroscopy) and antinuclear antibodies are of particular value in predicting this development.

    View this table:

    Prevalence of Raynaud's phenomenon in autoimmune rheumatic diseases

    Primary and secondary Raynaud's phenomenon are distinguished by a combination of clinical examination and laboratory investigations. Physical examination should include assessment of peripheral pulses, measurement of blood pressure in both arms, and examination of the neck for the tenderness often associated with a cervical rib. A negative test for antinuclear antibody in an otherwise healthy patient is reassuring but does not completely exclude subsequent development of an autoimmune rheumatic disease. Different types …

    View Full Text

    Sign in

    Log in through your institution

    Free trial

    Register for a free trial to thebmj.com to receive unlimited access to all content on thebmj.com for 14 days.
    Sign up for a free trial

    Subscribe