Letters

Apolipoprotein e4 allele and cognitive decline

BMJ 1995; 310 doi: http://dx.doi.org/10.1136/bmj.310.6975.330a (Published 04 February 1995) Cite this as: BMJ 1995;310:330

May be less relevant

  1. G B Frisoni,
  2. A Bianchetti,
  3. G Franceschini,
  4. S Govoni,
  5. M Trabucchi
  1. Staff specialist Head Alzheimer's Disease Unit, Ospedale S Cuore-FBF, I-25125 Brescia, Italy
  2. Professor of pharmacology Centre E Grossi Paoletti, Institute of Pharmacological Sciences, University of Milan, I-20162 Milan
  3. Professor of pharmacology Institute of Pharmacological Sciences, University of Milan, I-20133 Milan
  4. Profesor of neuropharmacology Geriatric Research Group, I-25122 Brescia

    EDITOR,—In their paper on the association of the e4 allele of apolipoprotein E and incidence of cognitive impairment in elderly men Edith Feskens and colleagues claim that 22% of incident cases of cognitive impairment can be attributed to the effect of the e4 allele.1 This contrasts with much higher figures previously reported in patients with Alzheimer's disease,2 3 but is in accordance with data that we collected on a series of patients with the disease.

    Attributable fraction is the proportion of cases that would be avoided by reducing risk to the level found in the lower risk …

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