Letters

Authors' reply

BMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6974.257a (Published 28 January 1995) Cite this as: BMJ 1995;310:257
  1. E S M De Lange De Klerk,
  2. J Blommers,
  3. D J Kuik,
  4. P D Bezemer,
  5. L Feenstra
  1. First investigator Research physician Biostatistician Head of department Vakgroep Epidemiologie en Biostatistiek, Faculteit der Geneeskunde, Vrije Universiteit, 1081 BT Amsterdam, Netherlands
  2. Professor of otolaryngology UZ Sint Rafael, Dienst ORL, 3000 Leuven, Belgium

    EDITOR,—The level of significance that we chose was, admittedly, an arbitrary cut off point. The difference in daily symptom score lingered around the 0.05 significance level. The estimate of the difference, however, was in our opinion—and to our disappointment—not clinically relevant. Even the clinical relevance of the upper limit of the 95% confidence interval of the difference in mean symptom scores over a year (0.83) must be questioned.

    The power calculation for the trial was based on the outcome measure “change in wellbeing score.”1 …

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