Author's replyBMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6971.58a (Published 07 January 1995) Cite this as: BMJ 1995;310:58
- Ivar A Mjor
- Professor College of Dentistry, University of Florida, Gainesville, FL 32610–0415, USA
EDITOR,—A large number of patients are needed to determine whether a side effect is significant. At an incidence of 1 in 1000 about 4000 patients receiving the same treatment have to be examined to confirm any reaction if 95% confidence intervals are used.1 Objectively diagnosed side effects to dental restorative materials are rare. Thus controlled clinical studies to establish their incidence are difficult and …
Log in using your username and password
Log in through your institution
Register for a free trial to thebmj.com to receive unlimited access to all content on thebmj.com for 14 days.
Sign up for a free trial