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BMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6971.58a (Published 07 January 1995) Cite this as: BMJ 1995;310:58
  1. Ivar A Mjor
  1. Professor College of Dentistry, University of Florida, Gainesville, FL 32610–0415, USA

    EDITOR,—A large number of patients are needed to determine whether a side effect is significant. At an incidence of 1 in 1000 about 4000 patients receiving the same treatment have to be examined to confirm any reaction if 95% confidence intervals are used.1 Objectively diagnosed side effects to dental restorative materials are rare. Thus controlled clinical studies to establish their incidence are difficult and …

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