ANY QUESTIONSBMJ 1995; 310 doi: https://doi.org/10.1136/bmj.310.6971.30 (Published 07 January 1995) Cite this as: BMJ 1995;310:30
- D Craig Brater
Are there any objective measurements of the potency of diuretics? If so, how much does adding 5 mg amiloride to 40 mg frusemide increase the potency?
Potency of diuretics is determined in several ways. Formal assessment requires studies in which the dose or concentration of the diuretic is related to response. From the studies you can construct a curve from which the dose or concentration causing half the maximal response can be derived. Relative potency among diuretics then compares the …