Skin necrosis induced by streptokinase

BMJ 1994; 309 doi: https://doi.org/10.1136/bmj.309.6967.1513c (Published 03 December 1994) Cite this as: BMJ 1994;309:1513
  1. Hermann Dass,
  2. Reinhard Fescharek
  1. Deputy commissioner for the graduated plan, Drug Surveillance Department, Behringwerke AG, PO Box 1140, D-35001 Marburg, Germany.

    EDITOR,—J Penswick and A L Wright report a case of skin necrosis possibly induced by treatment with streptokinase.1 Pathophysiologically they suspected “a variety of disturbances of the clotting and thrombolytic cascade,” but they fail to give any evidence for their suspicion. The clinical course of events is compatible with cholesterol crystal embolisation. Cholesterol crystal embolisation of the arteries of the skin may present as …

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