Derive reference range locallyBMJ 1994; 309 doi: https://doi.org/10.1136/bmj.309.6967.1511b (Published 03 December 1994) Cite this as: BMJ 1994;309:1511
- M K Hassan,
- R H Neary,
- J H Scarpello
- Senior registrar in clinical biochemistry Consultant in clinical biochemistry Consultant physician North Staffordshire Hospital, Stoke on Trent ST4 7PA.
EDITOR,—During the past decade measurement of the glycated haemoglobin concentration has become the gold standard for assessing glucose control in diabetes.1 Eric S Kilpatrick and colleagues identified a discrepancy between measurements of total haemoglobin A1 and haemoglobin A1c, but our experience indicates that this may not apply to other laboratories.
When we changed our analytical method to automated ion exchange chromatography (Glycomat, Ciba-Corning) we established our own reference range for a healthy population (n = …