Triglyceride concentration and coronary heart disease

BMJ 1994; 309 doi: https://doi.org/10.1136/bmj.309.6966.1440a (Published 26 November 1994) Cite this as: BMJ 1994;309:1440
  1. Alan M Garber,
  2. Andrew L Avins
  1. Associate professor, Stanford University and Department of Veterans Affairs, 3801 Miranda Avenue, Palo Alto, CA 94304, USA.
  2. Assistant professor, University of California, San Francisco, 74 New Montgomery Street, San Francisco, CA 94105, USA.

    EDITOR,—Despite the intuitive appeal of lowering the triglyceride concentration along with the cholesterol concentration when both are raised there is no evidence that this strategy is more effective than targeting treatment at cholesterol alone. Even treatments that raise triglyceride concentrations diminish the risk of coronary heart disease in hypercholesterolaemic subjects. In the Lipid Research Clinics coronary primary prevention trial, treatment with diet and cholestyramine resulted in a 19% reduction in the risk of coronary heart disease, despite an increase in serum triglyceride concentrations averaging …

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