BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6943.1580 (Published 11 June 1994) Cite this as: BMJ 1994;308:1580

Since 1987 AIDS vaccines have been tested in more than 1400 uninfected people and more, larger trials are planned (Science 1994;264:1072-4). Studies of intravenous drug users have shown up some of the practical problems. Most such drug users are interested in the idea of participating - until they discover that after taking the vaccine they would inevitably yield positive results in tests for HIV antibodies. Then most change their minds.

Lung transplantation may be the only hope of survival for children with disorders such as cystic fibrosis, but the immunosuppressive drugs that have to be given may cause great distress, says a review in “Thorax” (1994;49:437-9). In particular, the changes in body appearance such as cushingoid features, hypertrichosis, and gingival hypertrophy may “become intolerable for adolescent patients.” The result may be non- compliance with treatment and loss of the graft.

Infection of the genital tract is a known trigger of premature labour. This observation led to a clinical trial in South Africa of ampicillin and metronidazole in 81 women in active preterm labour (British Journal of Obstetrics and Gynaecology 1994;101:404-8). All were treated with hexoprenaline and indomethacin. Pregnancy was prolonged for 15 days in …

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