Acute renal failure associated with NSAIDSBMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6932.857d (Published 26 March 1994) Cite this as: BMJ 1994;308:857
- C A O'Callaghan
- Renal Unit, Guy's Hospital, London SE1 9RT.
Editor,--G W Smith and S B Cohen report on a 79 year old woman who was taking non-steroidal anti-inflammatory drugs and developed renal impairment and hyperkalaemia when a urinary tract infection was treated with trimethoprim.1 They unreasonably dismiss the non-steroidal anti-inflammatory drug as a possible cause of the renal disease.
Non-steroidal anti-inflammatory drugs inhibit the normal tonic renal vasodilatation induced by prostaglandin. Loss of this …