Acute renal failure associated with NSAIDS

BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6932.857d (Published 26 March 1994) Cite this as: BMJ 1994;308:857
  1. C A O'Callaghan
  1. Renal Unit, Guy's Hospital, London SE1 9RT.

    Editor,--G W Smith and S B Cohen report on a 79 year old woman who was taking non-steroidal anti-inflammatory drugs and developed renal impairment and hyperkalaemia when a urinary tract infection was treated with trimethoprim.1 They unreasonably dismiss the non-steroidal anti-inflammatory drug as a possible cause of the renal disease.

    Non-steroidal anti-inflammatory drugs inhibit the normal tonic renal vasodilatation induced by prostaglandin. Loss of this …

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