Letters

Infection with hepatitis C virus

BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6932.856a (Published 26 March 1994) Cite this as: BMJ 1994;308:856
  1. I Quinti,
  2. G Sacco,
  3. D El Salman,
  4. R Paganelli,
  5. M Fiorilli,
  6. F Aiuti,
  7. F Pandolfi
  1. Department of Allergy and Clinical Immunology, La Sapienza University of Rome, Rome, Italy
  2. Chair of Metodologia Clinica, Catholic University of Rome, Rome, Italy.

    Intravenous gammaglobulin may still infect patients

    Editor,--Transmission of hepatitis C virus has been shown in patients with common variable immunodeficiency receiving gammaglobulin replacement treatment.1 2 We have previously described the presence of antibodies to hepatitis C virus in commercial intravenous gammaglobulins.3 Although intravenous gammaglobulin prepared by a cold-ethanol fractionation procedure is regarded as safe, hepatitis C virus RNA has been detected in Cohn fraction II,4 in the final product, and in a few batches of recently prepared intravenous gammaglobulin in France.5

    We tested the hepatitis C virus status of 51 patients with common variable immunodeficiency …

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