Safety of tamoxifen

BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6927.534 (Published 19 February 1994) Cite this as: BMJ 1994;308:534
  1. G M Williams
  1. American Health Foundation, Valhalla, NY 10595, USA.

    EDITOR, - V Craig Jordan reports some of the preclinical toxicological findings on tamoxifen in his editorial.1 Though he states that tamoxifen “promotes hepatic tumours in rats,” he fails to note that tamoxifen is a strong liver carcinogen by itself in rats, producing tumours within six months and a high incidence by one year at doses that yield …

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