Intrauterine growth and serum cholesterol Link may be spurious

BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6927.532a (Published 19 February 1994) Cite this as: BMJ 1994;308:532
  1. M Mongelli,
  2. J Gardosi
  1. Perinatal Research and Monitoring Unit, Queen's Medical Centre, Nottingham NG7 2UH
  2. MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO9 4XY
  3. Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QR.

    EDITOR, - Studies of associations between birth variables and adult morbidity such as that by D J P Barker and colleagues are of epidemiological interest, but the results need to be interpreted with caution.1 Even within the limitations of 50 years old records the authors' main conclusion - that raised cholesterol concentrations in adult life are associated with impaired growth during late gestation - is difficult to accept on the basis of the data presented.

    It is difficult to infer growth retardation from any single measurement such as …

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