Colorectal Cancer: A Scientific PerspectiveBMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6924.348 (Published 29 January 1994) Cite this as: BMJ 1994;308:348
- R J Heald
A R Kinsella, P Schofield Cambridge University Press, £40, pp 159 ISBN 1-521-36199-0
Written by a scientist, Ann Kinsella and a surgeon, Philip Schofield, this excellent little book aims at unravelling the step by step genetic processes that lead to bowel cancer.
Morson's polyp-cancer sequence and the importance of the size of a benign tumour in its risk of malignant transformation are well known. Estimates of around 5-10 years for polyp to cancer seem reasonable, while the process from normal mucosa to cancer may take double this time. Surprisingly, without screening only about half of patients with familial polyposis coli have …