Monitor antibody levels after vaccination

BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6924.338b (Published 29 January 1994) Cite this as: BMJ 1994;308:338
  1. S Obaro,
  2. D C Henderson,
  3. M Monteil
  1. Department of Immunology, Chelsea and Westminster Hospital, London SW10 9NH.

    EDITOR, - The role of the spleen in protecting against overwhelming sepsis due to encapsulated bacteria has long been established, and animal studies have shown the importance of the spleen in clearing organisms that have been opsonised by complement.1 In animals that have undergone splenectomy the fixed macrophages of the liver take over this function, but high levels of specific capsular antibodies are required to facilitate hepatic clearance.2 Vaccination in patients who have undergone splenectomy aims to maintain high specific antibody levels. …

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