Early treatment of Parkinson's disease Open studies are unreliable

BMJ 1994; 308 doi: https://doi.org/10.1136/bmj.308.6923.272a (Published 22 January 1994) Cite this as: BMJ 1994;308:272
  1. V Myllyla,
  2. E Heinonen
  1. Department of Neurology, University Hospital of Oulu, Oulu, Finland Orion-Farmos Pharmaceuticals, Farmos Research, Neurological Products, Turku, Finland.

    EDITOR, - We wish to comment on the article by the Parkinson's Disease Research Group in the United Kingdom on early treatment of the disease.1

    Firstly, the study was open; open studies may undermine the reliability of clinical trials. The comparability of the three groups over time is a major concern in this trial: in the bromocriptine group there was a 69% drop out rate, whereas in the two other groups the drop out rate was around 30%. This may have diminished the comparability of …

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