Research Article

Symptoms after accelerated immunisation.

BMJ 1992; 304 doi: https://doi.org/10.1136/bmj.304.6841.1534 (Published 13 June 1992) Cite this as: BMJ 1992;304:1534
  1. M. E. Ramsay,
  2. M. Rao,
  3. N. T. Begg
  1. Immunisation Division, PHLS Communicable Disease Surveillance Centre, London.

    Abstract

    OBJECTIVE--To document the incidence of symptoms after accelerated immunisation with diphtheria-tetanus-pertussis vaccine. DESIGN--Controlled study of children immunised with adsorbed diphtheria-tetanus-pertussis vaccine at accelerated and standard schedules. SETTING--Colchester and north Hertfordshire. SUBJECTS--107 children scheduled to receive immunisation at 2, 3, and 4 months of age and 115 children scheduled to receive immunisation at 3, 4 1/2 to 5, and 8 1/2 to 11 months of age. MAIN OUTCOME MEASURES--Parentally recorded symptoms, axillary temperatures, and size of local redness and swelling at the injection site during the seven days after immunisation. RESULTS--In general symptoms occurred less frequently with the accelerated schedule. Proportions of parents reporting axillary temperatures greater than 37.2 degrees C or local redness or swelling greater than 2.5 cm after the third dose of vaccine were significantly reduced in the accelerated schedule group. CONCLUSION--Immunisation at 2, 3, and 4 months of age is likely to cause fewer reactions than immunisation at 3, 4 1/2 to 5, and 8 1/2 to 11 months of age.