Research Article

Genitourinary tract infections in pregnancy and low birth weight: case-control study in Australian aboriginal women.

BMJ 1991; 303 doi: https://doi.org/10.1136/bmj.303.6814.1369 (Published 30 November 1991) Cite this as: BMJ 1991;303:1369
  1. R Schultz,
  2. A W Read,
  3. J A Straton,
  4. F J Stanley,
  5. P Morich
  1. Department of Public Health, University of Western Australia, Nedlands.

    Abstract

    OBJECTIVE--To investigate the association between genital and urinary tract infections in pregnant Aboriginal women and low birth weight. DESIGN--Retrospective case-control study controlling for potential confounding variables. SETTING--Western Australia from 1985 to 1987. SUBJECTS--All Aboriginal women (n = 269) who had given birth to singleton infants weighing 2250 g or less (cases), and 269 randomly selected Aboriginal women who had given birth to singleton infants weighing 3000 g or more (controls). MAIN OUTCOME MEASURES--Proportions of women in case and control groups who had had genital and urinary tract infections; odds ratios for low birth weight when genitourinary tract infection was present; population attributable fraction of low birth weight to genitourinary tract infection. RESULTS--At the time of delivery 51% of women in the case group (109/215) had genitourinary tract infections compared with 13% of controls (35/266). After controlling for potential confounding variables the odds ratio for giving birth to infants weighing 2250 g or less when genitourinary tract infection was present was 4.0 (95% confidence interval 2.3 to 7.0). The proportion of infants with low birth weight attributable to genitourinary tract infection in the whole population of Aboriginal women was 32% (95% confidence interval 17% to 49%). CONCLUSIONS--There was a strong association between low birth weight and the presence of genitourinary tract infections in Aboriginal women both during pregnancy and at the time of delivery. A community intervention trial of screening and treatment of genitourinary infections in this population is recommended.