Research Article

Risk of tuberculosis in patients with HIV-I and HIV-II infections in Abidjan, Ivory Coast.

BMJ 1991; 302 doi: http://dx.doi.org/10.1136/bmj.302.6775.496 (Published 02 March 1991) Cite this as: BMJ 1991;302:496
  1. K M De Cock,
  2. E Gnaore,
  3. G Adjorlolo,
  4. M M Braun,
  5. M F Lafontaine,
  6. G Yesso,
  7. G Bretton,
  8. I M Coulibaly,
  9. G M Gershy-Damet,
  10. R Bretton
  1. Division of HIV and AIDS, Centers for Disease Control, Atlanta, Georgia.

    Abstract

    OBJECTIVE--To examine the association between HIV-II infection and tuberculosis. DESIGN--Cross sectional study comparing the prevalence of HIV-I and HIV-II infections in patients with tuberculosis and in blood donors. SETTING--Abidjan, Ivory Coast, west Africa. PATIENTS--2043 consecutive ambulant patients with tuberculosis (confirmed pulmonary, presumed pulmonary, or extrapulmonary) and 2127 volunteer blood donors. MAIN OUTCOME MEASURE--Prevalence of HIV-I and HIV-II infections as assessed by presence of serum antibodies. RESULTS--Overall rates of HIV infection were 40.2% in patients with tuberculosis (26.4% positive for HIV-I, 4.7% for HIV-II, and 9.0% for both); and 10.4% in blood donors (7.2% positive for HIV-I, 1.9% for HIV-II, and 1.3% for both). HIV-II infection was significantly more common in patients with all types of tuberculosis than in blood donors (97/2043, 4.7% v 40/2127, 1.9%; odds ratio 3.8%, 95% confidence interval 2.6 to 5.6). CONCLUSION--Both HIV-I and HIV-II infections are associated with tuberculosis in Abidjan. 35% of adult tuberculosis in Abidjan is attributable to HIV infection and 4% specifically to HIV-II.