Research Article

Evaluation of creatinine phosphokinase in screening patients for malignant hyperpyrexia.

Br Med J 1975; 3 doi: https://doi.org/10.1136/bmj.3.5982.511 (Published 30 August 1975) Cite this as: Br Med J 1975;3:511
  1. F R Ellis,
  2. I M Clarke,
  3. M Modgill,
  4. S Currie,
  5. D G Harriman

    Abstract

    Evidence is presented that serum creatinine phosphokinase (CPK) activity is of no direct value in screening patients for susceptibility to malignant hyperpyrexia and does not correlate with halothane-induced muscle contracture or the presence of myopathy. Widely differing CPK values were found at different times in the same people. In most "malignant hyperpyrexia" families the susceptible patients had either normal or inconsistently raised CPK values.