Research Article

Plasma corticotrophin levels in addison-schilder's disease.

Br Med J 1975; 3 doi: (Published 26 July 1975) Cite this as: Br Med J 1975;3:201
  1. L H Rees,
  2. D B Grant,
  3. J Wilson


    Raised plasma immunoreactive corticotrophin (ACTH) levels were found in five boys with the sex-linked disorder progressive leucodystrophy associated with adrenal insufficiency (Addison-Schilder's disease) and in a symptom-free brother of one of them. Similar ACTH concentrations were found using two antisera, one against the N-terminal part of the ACTH molecule and the other against the C-terminal part. In one patient the circulating ACTH had normal biological activity as measured using the cytochemical ACTH bioassay. Immunoreactive beta/-melanocyte-stimulating hormone was also determined in one patient and found to be raised.