Research Article

Growth hormone release inhibiting hormone: actions on thyrotrophin and prolactin secretion after thyrotrophinreleasing hormone.

Br Med J 1975; 3 doi: https://doi.org/10.1136/bmj.3.5975.67 (Published 12 July 1975) Cite this as: Br Med J 1975;3:67
  1. D Carr,
  2. A Gomez-Pan,
  3. D R Weightman,
  4. V C Roy,
  5. R Hall,
  6. G M Besser,
  7. M O Thorner,
  8. A S McNeilly,
  9. A V Schally,
  10. A J Kastin,
  11. D H Coy

    Abstract

    The hypothalamic tetradecapeptide growth hormone release inhibiting hormone (GH-RIH) blocked the thyrotrophin response to thyrotrophin-releasing hormone (TRH) in normal people and in patients with primary hypothyroidism. This inhibition was dose related. The TRH-induced prolactin release was not affected by GH-RIH. This dissociation of the thyrotrophin and prolactin responses to TRH by GH-RIH suggests that there are different mechanisms for release of thyrotrophin and prolactin and that only the former is affected by GH-RIH.