Papers And Originals

Blood Muramidase Activity in Colorectal Cancer

Br Med J 1974; 3 doi: (Published 14 September 1974) Cite this as: Br Med J 1974;3:662
  1. E. H. Cooper,
  2. R. Turner,
  3. L. Steele,
  4. J. C. Goligher


    The serum muramidase levels were measured in 128 patients with primary or metastatic colorectal cancer, 166 tumour-free patients after resection of a colorectal cancer, and 172 controls. Muramidase levels over 10 μg/ml were detected in 30%-39% of the tumour-bearing patients, in 8·2% of the tumour free, and in only 1·7% of the controls (normal level 6·68 ± 1·42 μg/ml). Long-term follow up indicated that raised levels may occur as a transient phenomenon in recurrent or metastatic disease. The likely relation of abnormal serum muramidase activity and stimulation of the reticuloendothelial system is discussed.