Blood Muramidase Activity in Colorectal CancerBr Med J 1974; 3 doi: https://doi.org/10.1136/bmj.3.5932.662 (Published 14 September 1974) Cite this as: Br Med J 1974;3:662
- E. H. Cooper,
- R. Turner,
- L. Steele,
- J. C. Goligher
The serum muramidase levels were measured in 128 patients with primary or metastatic colorectal cancer, 166 tumour-free patients after resection of a colorectal cancer, and 172 controls. Muramidase levels over 10 μg/ml were detected in 30%-39% of the tumour-bearing patients, in 8·2% of the tumour free, and in only 1·7% of the controls (normal level 6·68 ± 1·42 μg/ml). Long-term follow up indicated that raised levels may occur as a transient phenomenon in recurrent or metastatic disease. The likely relation of abnormal serum muramidase activity and stimulation of the reticuloendothelial system is discussed.