Papers And Originals

Oral Contraceptives and Increased Formation of Soluble Fibrin

Br Med J 1974; 3 doi: http://dx.doi.org/10.1136/bmj.3.5930.556 (Published 31 August 1974) Cite this as: Br Med J 1974;3:556

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  1. L. O. Pilgeram,
  2. J. Ellison,
  3. G. Von Dem Bussche

    Abstract

    Soluble fibrin was measured weekly for two months in 12 normal women and in 12 women on combined oestrogen-progestogen therapy (Ortho-Novin, Norinyl, Enavid, Ovral, Ovulen, Demulen). Plasma soluble fibrin concentration in women on oral contraceptives showed an increase of 97·2% (P <0·001) above that of normal women. In three cases, where each woman on the oral contraceptive served as her own control, stopping medication led to a return to normal of the plasma content of soluble fibrin.