Effect of Prolonged Thiazide Treatment on Renal Lithium ClearanceBr Med J 1974; 3 doi: http://dx.doi.org/10.1136/bmj.3.5924.143 (Published 20 July 1974) Cite this as: Br Med J 1974;3:143
- V. Petersen,
- S. Hvidt,
- K. Thomsen,
- M. Schou
Renal lithium clearances were determined after the administration of a small test dose of lithium carbonate in 22 patients when they were on long-term treatment with thiazides and when they were not on such treatment. Thiazide administration led to a 24% reduction in the lithium clearance. Diuretic drugs should be used with caution in patients given lithium treatment, and lithium should be used with caution in patients receiving diuretic treatment.