Papers And Originals

Glomerular Deposition of Properdin in Henoch-Schönlein Syndrome and Idiopathic Focal Nephritis

Br Med J 1973; 3 doi: https://doi.org/10.1136/bmj.3.5875.326 (Published 11 August 1973) Cite this as: Br Med J 1973;3:326
  1. D. J. Evans,
  2. D. Gwyn Williams,
  3. D. K. Peters,
  4. J. G. P. Sissons,
  5. J. M. Boulton-Jones,
  6. C. S. Ogg,
  7. J. S. Cameron,
  8. B. I. Hoffbrand

    Abstract

    Biopsy of renal tissue from four patients with idiopathic focal nephritis and three patients with Henoch-Schönlein syndrome showed that C3 and properdin were deposited with IgA in the glomerular mesangium, C1q could not be detected. These observations suggest that glomerular injury in disorders characterized by mesangial deposits of IgA and C3 is mediated via the properdin system.