Papers And Originals

Reduction of Absorption of Paracetamol by Activated Charcoal and Cholestyramine: A Possible Therapeutic Measure

Br Med J 1973; 3 doi: https://doi.org/10.1136/bmj.3.5871.86 (Published 14 July 1973) Cite this as: Br Med J 1973;3:86
  1. B. Dordoni,
  2. R. A. Willson,
  3. R. P. H. Thompson,
  4. Roger Williams

    Abstract

    The absorption of an oral 2-g dose of paracetamol was markedly reduced by the simultaneous oral administration of either activated charcoal or cholestyramine but was only slightly reduced when the adsorbents were given 60 minutes after the paracetamol. Since the absorption of a larger dose of the drug will probably be slow, the administration of adsorbents may be of value even when delayed several hours.