Clinical Problems: Levodopa Therapy of Patients with Parkinsonism and Heart DiseaseBr Med J 1972; 3 doi: https://doi.org/10.1136/bmj.3.5825.512 (Published 26 August 1972) Cite this as: Br Med J 1972;3:512
- Ramon B. Jenkins,
- Sander H. Mendelson,
- Sofjan Lamid,
- Harold L. Klawans
Forty patients with Parkinsonism and heart disease were studied before and during the administration of levodopa. Patients with increasing angina, myocardial infarction within the previous year, pre-existing severe postural hypotension, or transient cerebral ischaemia were excluded. Thirty-eight patients showed no adverse effects; angina improved in one patient but later worsened; one patient died of myocardial infarction after a severe gastrointestinal haemorrhage. Therapy with levodopa appears to pose little increased hazard to patients with most forms of heart disease. Inpatient monitoring is recommended at the beginning of therapy, and antiarrhythmic agents should be used when required.
Log in using your username and password
Log in through your institution
Register for a free trial to thebmj.com to receive unlimited access to all content on thebmj.com for 14 days.
Sign up for a free trial