Papers And Originals

Prostaglandin-like Activity in Ocular Inflammation

Br Med J 1972; 3 doi: (Published 19 August 1972) Cite this as: Br Med J 1972;3:452
  1. K. E. Eakins,
  2. R. A. F. Whitelocke,
  3. A. Bennett,
  4. A. C. Martenet


    Aqueous humour samples from untreated patients with acute anterior uveitis were found to contain substantial amounts of prostaglandin-like activity. Little activity was found in aqueous from patients treated with steroids, and none (<2 ng/ml) was detected in aqueous from the uninflamed eyes of patients with cataract. Alkaline hydrolysis of the samples from inflamed eyes suggested the presence of both E and F prostaglandin-like activity. These results show that prostaglandins may be involved in acute anterior uveitis.