Papers And Originals

Trimethoprim and Sulphamethoxazole in Typhoid Fever in Children

Br Med J 1971; 3 doi: http://dx.doi.org/10.1136/bmj.3.5777.738 (Published 25 September 1971) Cite this as: Br Med J 1971;3:738
  1. J. N. Scragg,
  2. C. J. Rubidge

    Abstract

    One hundred and three children with proved typhoid fever were treated with trimethoprim-sulphamethoxazole, and the results compared with those of a further 40 children treated with chloramphenicol. The bacteriological response to trimethoprim-sulphamethoxazole was unsatisfactory. From this study it seems that at present chloramphenicol is still the treatment of choice for typhoid fever. In view of the haematological changes occurring during therapy with trimethoprim-sulphamethoxazole caution is necessary and monitoring of the blood picture advisable, even at the recommended dose.