Papers And Originals

Leucopenia Associated with Trimethoprim-Sulphamethoxazole after Renal Transplantation

Br Med J 1971; 3 doi: https://doi.org/10.1136/bmj.3.5775.610 (Published 11 September 1971) Cite this as: Br Med J 1971;3:610
  1. B. Hulme,
  2. D. S. Reeves

    Abstract

    Four patients who had received cadaveric renal allografts developed a profound and sustained leucopenia in association with a trimethoprim-sulphamethoxazole preparation. Ten other cadaveric renal allograft recipients received identical chemotherapy with no adverse effects. Statistical analysis showed that the association of leucopenia and trimethoprim-sulphamethoxazole therapy was dependent on the time after the transplantation procedure and was not related to the dosage of immunosuppressive chemotherapy or renal function.