Papers And Originals

Trial of Maintenance Therapy in Schizophrenia

Br Med J 1971; 3 doi: (Published 11 September 1971) Cite this as: Br Med J 1971;3:599
  1. J. P. Leff,
  2. J. K. Wing


    A double-blind, placebo-controlled trial was carried out to determine the value of maintenance therapy with phenothiazines in a population of outpatients who had recently recovered from an acute episode of schizophrenia. The drug was shown to be significantly more effective than the placebo in preventing relapse. The relationship of the trial patients to the population from which they were selected was defined in terms of clinical, historical, and social data. Maintenance therapy seems of little value in patients with a good prognosis and in the severely ill, but it is of value in the indeterminate group between these two extremes.


    • * Report to the Medical Research Council Committee on Clinical Trials in Psychiatry.

      Members of Committee on Clinical Trials in Psychiatry: Professor Sir Austin Bradford Hill, F.R.S. (chairman), Dr. R. H. Cawley, Professor M. G. Gelder, Professor D. A. Pond, Professor W. Linford Rees, Professor T. Ferguson Rodger, Professor M. Roth, Professor M. Shepherd, Dr. I. Sutherland, and Dr. M. H. Lader (secretary).