Papers And Originals

Comparative Double-blind Trial of Cephalexin and Ampicillin in Treatment of Urinary Infections

Br Med J 1971; 3 doi: https://doi.org/10.1136/bmj.3.5768.215 (Published 24 July 1971) Cite this as: Br Med J 1971;3:215
  1. J. A. Davies,
  2. J. E. M. Strangeways,
  3. R. G. Mitchell,
  4. L. J. Beilin,
  5. J. G. G. Ledingham,
  6. J. M. Holt

    Abstract

    Cephalexin was compared with ampicillin in the treatment of urinary tract infections by a random double-blind technique. Both drugs were found to be equally effective. In 21 out of 31 patients treated with cephalexin and in 20 out of 31 treated with ampicillin the urine was sterile three weeks after starting therapy. The bacteriological findings at one and eight weeks were also similar in both groups. No serious adverse reactions were attributable to cephalexin, which seemed to be tolerated rather better than ampicillin.