Mechanism of Hyperventilation in Acute Cerebrovascular AccidentsBr Med J 1971; 3 doi: https://doi.org/10.1136/bmj.3.5765.9 (Published 03 July 1971) Cite this as: Br Med J 1971;3:9
- D. J. Lane,
- M. W. Rout,
- D. H. Williamson
Lumbar cerebrospinal fluid and arterial blood acid-base state were assessed in 19 patients within 24 hours of an acute cerebrovascular accident. Those with haemorrhage into the C.S.F. showed a lower C.S.F. pH and higher C.S.F. lactate than those without haemorrhage but the Pco2, was similar in the two groups, suggesting that this greater C.S.F. acidity was not responsible for a greater degree of hyperventilation. In those without haemorrhage an inverse relation was found between C.S.F. pH and arterial Pco2, suggesting that a non-chemical ventilatory drive—for example, due to central neurological damage—was responsible for the acid-base changes observed.