Papers And Originals

Plasma 11-Hydroxycorticoid Levels after Carbenoxolone Sodium

Br Med J 1970; 3 doi: https://doi.org/10.1136/bmj.3.5721.498 (Published 29 August 1970) Cite this as: Br Med J 1970;3:498
  1. D. Mattingly,
  2. Christine Tyler,
  3. Elaine Bilton

    Abstract

    A definite rise in plasma 11-hydroxycorticoid levels has been shown in eight patients with duodenal ulcer following the oral administration of carbenoxolone sodium. A similar rise was seen in one patient with sarcoidosis whose pituitary A.C.T.H. secretion had been acutely suppressed with dexamethasone. No such rise, however, was seen in three patients suffering from adrenal insufficiency. It is suggested that carbenoxolone acts directly on the adrenal cortex, causing an increased production of corticosteroids.